Grey's Anatomy revolves around the personal and professional lives of the doctors at Seattle's Grace Hospital, and examines the complex relationships involving Meredith Grey (Ellen Pompeo), the bumbling George O'Malley (T.R. Knight), Addison Forbes Montgomery (Kate Walsh), and the arrogant Preston Burke (Isaiah Washington). Grey's Anatomy also stars Sandra Oh, Justin Chambers, and Chandra Wilson. The show's successful formula relies on mixing intense medical procedures with its characters' emotional struggles. This collection includes series 1 to 5 of the hit medical show.